Oral Solid Dosage Form
Prescriptions for successful solutions
阿里彩票登陆平台 www.o1e1e.com.cn While an apple a day keeps the doctor away (and the teacher happy) there comes a time, in almost everyone's life, when medication - in tablet form - is needed. Our knowledge of the structure function of polymers, combined with our extensive product line can help you bind, coat, dissolve, and effectively deliver complex drug molecules where and when they're needed - making medication easier to swallow. And, easy to swallow medication often yields better patient compliance, which, in turn, yields better outcomes for everyone - a winning scenario. From concept to commericialization, working with Ashland makes medicine easy to swallow.
Ashland is unsurpassed in its ability to develop solutions for effective and efficient solutions to deliver today's complex drug molecules where and when they are needed. Our centers of excellence and manufacturing sites operate in accordance with cGMP standards. Our various chemistries and technologies are supported by a global team of research and development scientists. Ashland stands ready collaborate with you on new solutions to help take you from concept to commercialization. Our solutions include:
- Increasing the solubility of active pharmaceutical ingredients with low or no solubility
- Designing modified-release products to meet targeted release profiles
- Reducing tablet size while maintaining active pharmaceutical ingredient load
- Improving disintegration time of orally disintegrating tablets
- Understanding implications of continuous manufacturing technology for oral dosage production
Ongoing research provides a foundation for advanced technical solutions to address these and future formulation and manufacturing challenges. Ashland provides formulators with industry-changing technologies and unique opportunities for research and development collaboration.
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Aqualon? ethylcellulose (EC) is a cellulose ether distinguished by its versatility.
Aquarius? film coating systems
Our line of fully formulated, easily dispersed and ready-to-use Aquarius? film coating systems have a range of functions to suit almost any core. With our wide selection of film coating choices, we can provide an optimal coating for your unique formulation. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Informa...
AquaSolve? hypromellose acetate succinate
AquaSolve? HPMCAS for pharmaceutical applications is a cellulosic polymer with four substituents randomly substituted on the available hydroxyl groups with the following mass content: methoxyl, 12–18 wt%; hydroxypropoxy, 4–23 wt%; acetyl, 2–16 wt% and succinoyl, 4–28 wt%. It is white to off-white in color and has a faint acetic acid-like odor and a barely detectable taste. AquaSolve HPMCAS is available in several grades for pharmaceutical a...
Benecel? methylcellulose and hypromellose
Benecel? methylcellulose and hypromellose (hydroxypropyl-methylcellulose or HPMC) are versatile excipients with a variety of applications. High-viscosity grades are widely used in hydrophilic matrix controlled-release systems. Low-viscosity grades are used for rheology control and as tablet binders. Benecel Grades Available -->
Blanose? sodium carboxymethylcellulose
Blanose™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried. Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its abil...
CAVAMAX? native cyclodextrins
The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation. The number of glucose units in the ring determines the internal diameter of the cavity and its volume, as the height of the cyc...
Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.
Natrosol™ hydroxyethylcellulose (HEC), a nonionic, water-soluble polymer, is a white, free-flowing granular powder. It is made by reacting ethylene oxide with alkali-cellulose under rigidly controlled conditions. Purified HEC for personal care and cosmetic applications is typically sold at 95.0 percent minimum purity (dry basis). Solutions of Natrosol HEC are pseudoplastic or shear-thinning. As a result, personal care products formula...
Aqualon? sodium carboxymethylcellulose
Aqualon™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried. Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its ability to...
Ashland offers a comprehensive range of Plasdone povidones (PVP). Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in sol...
Plasdone? S-630 copovidone
Plasdone™ S-630 copovidone is a tablet binder, matrix polymer for solid-dispersion formulations and film former for topical applications. It is commonly used to enhance the solubility of active pharmaceutical ingredients and increase bioavailability of poorly soluble drugs through the formation of melt-extruded or spray-dried solid dispersions.
Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dis...
Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a water-miscible polar aprotic solvent with high interfacial activity. It is used as a drug solubilizer and penetration enhancer in human topical dosage forms, and for the same purposes in parenteral and topical veterinary products. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refe...
Cavitron* cyclodextrin and CAVASOL* cyclodextrin
The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-?- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable ...
Aquarius? preferred film coating systems
Aquarius Preferred film coating systems disperse easily in water. These film coatings are applicable to both pharmaceutical and nutraceutical solid dosage forms. Ashland formulators have access to an unrivaled range of cellulosic and other polymeric excipients, enabling Aquarius film coating systems to be tailored to meet exacting requirements. To maximize the efficiency of the coating application process, high-solids loadings are desirable. By r...
Aquarius? Control film coating systems
The Aquarius Control film coating systems consist of two types of coatings. Aquarius Control ENA film coating systems are delayed-release (enteric) coatings that are designed to protect active pharmaceutical ingredients (APIs) that degrade in gastric fluid, or to prevent the release of APIs that may irritate the gastric mucosa. Aquarius Control SRX film coating systems are sustained-release coatings for APIs that are most effective when released ...
Aquarius? Prime film coating systems
Aquarius Prime film coating systems disperse easily in water and are applied to immediate-release dosage forms. Film coatings for immediate-release tablet-coating applications are typically comprised of a polymer, a plasticizer and optional pigment/opacifier. Aquarius Prime film coating systems are available in clear and white formulations off the shelf. Aquarius Prime film coating systems can be matched to customers’ existing HPMC fil...
Aquarius? Protect film coating systems
Aquarius™ Protect is a premium multi-functional barrier coating system to effectively reduce moisture uptake and mask against offensive taste and odor. For easier usability, Aquarius™ Protect is a fully formulated, ready-mixed coating that disperses quickly in water or solvent and is available in clear, white and color matched versions. Aquarius™ Protect delivers superior barrier properties and efficient flexible processing, wit...
Aquarius? Genesis film coating systems
who helps you get to the finish line faster?__we do.introducing aquarius? genesis film coating systemAshland has a new, high-solids film-coating system for immediate-release applications. The Aquarius Genesis film coating is designed for application at up to 35% solids while producing films with outstanding strength, adhesion and smoothness. The pharmaceutical industry is moving from traditional batch manufacturing to continuous manufacturin...